As was completed during the 2021 - 2022 academic year, we will be sending out one seminal Neurology article per week, with an associated summary completed by our residents.  All papers that are sent out were hand-chosen by our wonderful faculty, and were chosen based on their relevance and significance to the field.  During this round, there will be a mix of "recycled" articles and summaries from the 2021 - 2022 academic year, as well as new articles and summaries for this year (as notated below). 

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Week 1 - Summary  |  Article

Tissue Plasminogen Activator for Acute Ischemic Stroke: NINDS rt-PA Study Group (NEJM 1995)

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Week 2 - Summary  |  Article

Late-life Migraine Accompaniments as a Cause of Unexplained Transient Ischemic Attacks (Canadian J. Neurosci, 1980)

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Week 3 - Summary  |  Article

ELLDOPA trial: Earlier versus Later Levodopa Therapy in Parkinson Disease (NEJM 2004)

 

Week 4 - Summary  |  Article

Intramuscular Interferon Beta-1a Therapy Initiated During a First Demyelinating Event in Multiple Sclerosis (The CHAMPS trial, NEJM 2000)

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Week 5 - Summary  |  Article

Effect of Acetazolamide on Visual Function in Patients with Idiopathic Intracranial Hypertension and Mild Visual Loss (The Idiopathic Intracranial Hypertension Treatment trial, JAMA 2014)

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Week 6 - Summary  |  Article

Intramuscular vs. Intravenous Therapy for Prehospital Status Epilepticus (RAMPART Trial, NEJM 2012)

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Week 7 - Summary  |  Article

A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus (The Veterans Affairs Status Epilepticus Cooperative Study Group, NEJM 1998)

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Week 8 - Summary  |  Article

MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset (The WAKE UP Trial, NEJM 2018)

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Week 9 - Summary  |  Article

The Multicenter Randomized CLinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands (MR CLEAN, NEJM 2015)

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Week 10 - Summary  |  Article (NEW article)

Thrombectomy for Stroke at 6-16hrs with Selection by Perfusion Imaging (DEFUSE-3, NEJM 2018)

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Week 11 - Summary  |  Article

Randomized trial of Three Anti-Convulsant Medications for Status Epilepticus (ESETT, NEJM 2019)

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Week 12 - Summary  |  Article (NEW article)

Incidence and mechanisms of cardiorespiratory arrest in epilepsy monitoring units (MORTEMUS): a retrospective study (Lancet, 2013)

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Week 13 - Summary  |  Article 

A randomized controlled trial of corticosteroids in the treatment of acute optic neuritis (ONTT, NEJM 1992)

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Week 14 - Summary  |  Article (NEW Article)

Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children (Neurology, 2013)

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Week 15 - Summary  |  Article (NEW Article)

Sensitization of meningeal sensory neurons and the origin of headaches (Letters to Nature, 2015) 

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Week 16 - Summary  |  Article (NEW Article)

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma (NEJM 2005)

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Week 17 - Summary  |  Article 

A randomized trial comparing intravenous immune globulin and plasma exchange in guillan-barre syndrome (NEJM 1992)

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Week 18 - Summary  |  Article (NEW Article)

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3, Lancet 2019)

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Week 19 - Summary  |  Article (NEW Article)

Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis (CREST study, NEJM 2010)

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Week 20 - Summary  |  Article (NEW Article)

‘Visual snow’–a disorder distinct from persistent migraine aura (Brain, 2014)

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Week 21 - Summary  |  Article 

Randomized Delayed-Start Trial of Levodopa in Parkinson’s Disease (NEJM 2019)

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Week 22 - Summary  |  Article 

Multiple Sclerosis Risk After Optic Neuritis: Final Optic Neuritis Treatment Trial Follow-up (Arch Neurol 2008)

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Week 23 - Summary  |  Article (NEW Article)

Definition and Consensus Diagnostic Criteria for Neurosarcoidosis: From the Neurosarcoidosis Consortium Consensus Group (JAMA Neurology 2018)

 

Week 24 - Summary  |  Article 

The SANAD (Standard and New Anti-Epileptic Drugs Project) study of effectiveness of valproate, lamotrigine, or topiramate for generalized and unclassifiable epilepsy (Lancet 2007)

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Week 25 - Summary  |  Article 

The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded, randomized controlled trial (Lancet 2007)

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Week 26 - Summary  |  Article (NEW Article)

Safety and efficacy of Edaravone in well-defined patients with ALS: a randomized, double-blind, placebo-controlled trial (Lancet Neurology, 2017)

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Week 27 - Summary  |  Article (NEW Article)

Hypothermia vs. Normothermia after out-of-hospital cardiac arrest (NEJM 2021)

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Week 28 - Summary  |  Article 

A double-blind, delayed start trial of Rasagiline in Parkinson's Disease (NEJM 2009)

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Week 29 - Summary  |  Article (NEW Article)

Lacunar Strokes and Infarcts: A Review (Neurology, 1983)

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Week 30 - Summary  |  Article (NEW Article)

HINTS to Diagnose Stroke in the Acute Vestibular Syndrome (Stroke, 2009)

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Week 31 - Summary  |  Article

The Fellow Eye in NAION: Report from the IONDT Follow-up Study (Am J Ophthalmology, 2002)

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Week 32 - Summary  |  Article

Phase 2 Study of a Temozolomide-Based Chemoradiation Therapy Regimen for High-Risk, Low-Grade Gliomas (Int J Rad Onc, 2020)

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Week 33 - Summary  |  Article (NEW Article)

Hypothalamic Activation in Cluster Headache Attacks (Lancet, 1998)

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Week 34 - Summary  |  Article (NEW Article)

Electrodiagnostic Criteria for diagnosis of ALS (Clinical Neurophysiology 2008)

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Week 35 - Summary  |  Article (NEW Article)

Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage (ATACH-2, NEJM 2016)

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Week 36 - Summary  |  Article (NEW Article)

Operational classification of seizure types by the International League Against Epilepsy (Epilepsia 2017)

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Week 37 - Summary  |  Article

Intravenous immune globulin for the treatment of CIDP (ICE Study): a randomized placebo-controlled trial (Lancet 2008)

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Week 38 - Summary  |  Article (NEW Article)

High-dose Atorvastatin after Stroke or Transient Ischemic Attack (SPARCL, NEJM 2006)

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Week 39 - Summary  |  Article (NEW Article)

Ocrelizumab vs. Placebo in Primary Progressive MS (NEJM 2017)

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Week 40 - Summary  |  Article 

Triptans in Migraine: detailed results and methods of a meta-analysis of 53 trials (Cephalalgia, 2002)

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Week 41 - Summary  |  Article 

Detection of electrographic seizures with cEEG monitoring in critically-ill patients (Neurology 2004)

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Week 42 - Summary  |  Article (NEW Article)

Fetal loss and malformations in the MONEAD study of pregnant women with epilepsy (Neurology 2020)

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Week 43 - Summary  |  Article (NEW Article)

Brain Tissue Oxygen Monitoring and Management in Severe Traumatic Brain Injury (BOOST-II): a Phase II Randomized Trial (Crit Care Med 2017)